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Adult patients with cirrhosis were divided into 2 groups: Group 1 included patients with a history of SBP who were initiated on ciprofloxacin or norfloxacin, or Bactrim, i.e., patients on secondary prophylaxis for SBP

Conversely, at higher concentrations, it tends to accumulate within the nonpolar chains of the phospholipid bilayer ( In vivo studies on rats showed poor absorption of orally administered curcumin, with more than 90% excreted in feces within 72 h ( Plasma concentrations remained minimal, even at high doses, with most curcumin localized in the small intestine and little reaching systemic circulation, resulting in a bioavailability of approximately 1% ( 8.2 Metabolism and elimination of curcumin Curcumins bioavailability in humans is mostly limited by poor intestinal absorption, rapid hepatic metabolism, and rapid systemic elimination, even at high doses of 12 g/day ( Figure 4

185 WadaK.HiratakeJ.IrieM.OkadaT.YamadaC.KumagaiH.et al (2008)

Rosell R, Jain A, Codony-Servat J, Jantus-Lewintre E, Morrison B, Ginesta JB, et al